| Software Products |
| The increasing demand for Quality by Design (QbD) in analytical sciences is a logical consequence of the often chaotic methods, that are sometimes developed by trial and error in the validation process of HPLC methods. To ensure a higher standard of method quality, the Federal Drug Administration (FDA) has recently demanded a more systematic Design of Experiments.
The Molnár-Institute has been proclaiming this type of approach since over 20 years, contributing to the development of the DryLab® software with LCResources under the leadership of Lloyd R.Snyder. Using DryLab the accurate preparation of experiments is initiated achieving useful and reproducible results. Additionally, PeakMatch helps the user to ensure safe and precise data entry into DryLab®. All software packages support the user by assuring an organized and systematic modelling of experiments, supplying an increased conscience and comprehension of how the substances in use really are behaving and efficiently further the success of your chromatographic work.
The above figure shows a three-dimensional resolution cube (top right side) of a Design Space (DS) with 3 factors: Gradient time (tG) (=x-axis), temperature (T) (=z-axis) and ternary composition (=y-axis) % MeOH in AN. The front page of the cube is shown on the top left. Red color indicates robust regions, blue color shows bad separation zones. Another problem is shown in the picture below: How can we replace Acetonitrile by Methanol? Based on 3x4 experiments we can predict a Design Space with more than 1,000,000 virtual experiments and find, that the most robust region is in a methanol rich part of the DS (picture on the right). The savings are quite considerable.
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